Zn2+ at a cellular crossroads

Colposcopy at a crossroads.

New cervical cancer prevention strategies are arising from rapidly improving insight into human papillomavirus (HPV) natural history and cervical carcinogenesis, challenging the conventional roles of cytology and colposcopically directed biopsy as the reference standards of screening and diagnosis, respectively. HPV testing has high sensitivity but mediocre specificity and positive predictive v...

FoxOs at the Crossroads of Cellular Metabolism, Differentiation, and Transformation

Forkhead transcription factors of the FoxO subfamily are emerging as a shared component among pathways regulating diverse cellular functions, such as differentiation, metabolism, proliferation, and survival. Their transcriptional output is controlled via a two-tiered mechanism of phosphorylation and acetylation. Modest alterations of this balance can result in profound effects. The gamut of phe...

AGCVIII kinases: at the crossroads of cellular signaling.

AGCVIII kinases regulate diverse developmental and cellular processes in plants. As putative mediators of secondary messengers, AGCVIII kinases potentially integrate developmental and environmental cues into specific cellular responses through substrate phosphorylation. Here we discuss the functionality and regulation of AGCVIII kinases. Specifically, we question the view that activities of AGC...

Wireless at a Crossroads

As they say, all good things must come to an end. After years of record profits and soaring subscriber numbers, the U.S. wireless market is now becoming saturated, with over 90% of adults in the U.S. owning a cell phone, according to Pew Research Center. The heady growth cannot continue without another swell of innovation spurring new sales, which does not appear immediately forthcoming. Pundit...

Managed care at a crossroads.